Management of Childhood Malignant Brain Tumor based on WHO 2016 Classification

A clinical perspective on the 2016 WHO brain tumor classification and routine molecular diagnostics.

The 2007 World Health Organization (WHO) classification of brain tumors did not use molecular abnormalities as diagnostic criteria. Studies have shown that genotyping allows a better prognostic classification of diffuse glioma with improved treatment selection. This has resulted in a major revision of the WHO classification, which is now for adult diffuse glioma centered around isocitrate dehyd...

Malignant Brain Tumors in Childhood

Although most brain tumors are sporadic, a number of pediatric brain tumor presentations are associated with recognized genetic syndromes. About 15–20% of children with neurofibromatosis (NF1) present with CNS neoplasms, usually gliomas of the optic pathways or low-grade tumors of the diencephalon, cerebral hemispheres, or posterior fossa (2). Low-grade gliomas associated with NF1 may be less a...

Brain tumor classification based on EEG hidden dynamics

The hard problem of brain tumor detection based on rest EEG analysis is investigated, relying on the hypothesis that the EEG signal contains more hidden useful information than what is clinically employed. A nonlinear analysis is applied to the pair (F3, F4) of EEG leads, that describe the electrical activity of the left and right brain hemisphere respectively. The hidden dynamic of the pair (F...

Brain tumor classification based on long echo proton MRS signals

There has been a growing research interest in brain tumor classification based on proton magnetic resonance spectroscopy (1H MRS) signals. Four research centers within the EU funded INTERPRET project have acquired a significant number of long echo 1H MRS signals for brain tumor classification. In this paper, we present an objective comparison of several classification techniques applied to the ...

Recurrent Malignant Primary Brain Tumor: the Pathophysiology and Management